Set in the fictional Eastern European country of Ghulovka, amidst a terrible civil war, Affliction allows players to take on the role of Vasya, a patient plagued by nightmares and fractured memories, who awakes inside of a cell in a bizarre research facility where grim human experiments are taking place. With no memory of their reason for being there, players are forced to fight for their survival through a hellish catastrophe while frantically seeking answers to discover the truth behind their identity and unveil the mystery surrounding the horrific true purpose of the complex.